Gestational diabetes & diabetes in pregnancy
Pre‐Existing Diabetes and Prediabetes in Pregnancy: Evaluation on Glycaemic Control, Pregnancy Outcomes and Clinical Gaps
Authors' conclusion
Multidisciplinary care enhanced glycaemic control and reduced macrosomia, but women with T1DM remain at increased risk of preterm delivery and neonatal morbidity. Enhanced preconception care, retinopathy screening and adoption of real-time CGM may improve outcomes in Asian women with pre-existing diabetes in pregnancy.
Study context
- Population
- Pregnancies with pre-existing diabetes or prediabetes at a Singapore tertiary hospital, 01/01/2022–31/12/2024; median maternal age 33 years, pre-pregnancy body mass index (BMI) 29.3 kg/m²
- Participants
- 289 pregnancies
- Exposure
- Outcomes by diabetes subtype: T2D vs prediabetes vs T1D
- Outcome
- HbA1c across trimesters
Methodological detailssingle-centre, multiethnic cohort
- Single-centre
- Multiethnic cohort
Main finding
As reported in the abstract
- HbA1c improved from 7.0% to 6.1% across trimesters
- p < 0.00
Observational data: associations, not effects.
Further findings
Preterm birth
Macrosomia (≥ 4 kg)
- Macrosomia in infants
- 4.2%
Retinopathy screening and device use
- Retinopathy screening completed
- 67.6%
- Continuous glucose monitoring (CGM) or pump devices were not utilised
LGA (Singapore reference) · third trimester
- Third trimester HbA1c < 6.5% associated with lower odds of LGA
- Multivariate logistic regression
Original publication
Pre‐Existing Diabetes and Prediabetes in Pregnancy: Evaluation on Glycaemic Control, Pregnancy Outcomes and Clinical Gaps. Diabetes Obes Metab. Published 2 March 2026. doi:10.
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