Gestational diabetes & diabetes in pregnancy
Associations of biochemical and metabolic markers with pregnancy outcomes in women with and without gestational diabetes mellitus: A prospective cohort study in eastern China
Authors' conclusion
Distinct biochemical profiles were observed between GDM and NGDM pregnancies. Albumin and creatinine may serve as simple, cost-effective indicators of reduced obstetric risk among normoglycaemic women. Incorporating these routinely measured markers into prenatal screening could improve individualized risk prediction and early intervention strategies..
Study context
- Population
- Pregnant women with and without gestational diabetes mellitus (GDM) at Shandong Provincial Third Hospital, eastern China
- Participants
- 246 women
- Exposure
- GDM vs non-GDM pregnancies
- GDMn = 123
- Non-GDM (NGDM)n = 123reference
- Outcome
- Associations of biochemical markers (fasting glucose, HbA1c, lipids, liver and kidney function, OGTT) with adverse pregnancy outcomes (caesarean section, macrosomia, PROM), adjusted for age, BMI and gestational weight gain
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Alkaline phosphatase (ALP) and direct bilirubin higher in NGDM women
- GDM vs NGDM: P < 0.001
- GDM vs NGDM: P = 0.028
Observational data: associations, not effects.
Further findings
Macrosomia per higher serum albumin, NGDM women
- aOR
- 0.43 (95% CI 0.20-0.93)
- Higher albumin also associated with lower odds of premature rupture of membranes (PROM) in NGDM women
- Multivariable logistic regression adjusted for age, BMI, gestational weight gain
Macrosomia per creatinine, NGDM women
- aOR
- 0.75 (95% CI 0.60-0.94)
Original publication
Associations of biochemical and metabolic markers with pregnancy outcomes in women with and without gestational diabetes mellitus: A prospective cohort study in eastern China. Diabet Med. Published 28 February 2026. doi:10.
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