Gestational diabetes & diabetes in pregnancy
Circulating protein biomarkers of physical fitness associated with cardiometabolic risk in women after gestational diabetes: a PONCH study
Authors' conclusion
This study identified circulating proteins linked to physical fitness and cardiometabolic health in women after GDM.
Study context
- Population
- Women 10 years after gestational diabetes mellitus (GDM), post-GDM PONCH-cohort
- Participants
- 38 women
- Outcome
- Serum proteins associated with aerobic capacity and muscle strength
- Follow-up
- 10 years after GDM
Methodological detailsmass spectrometry-based proteomics, FDR-corrected Spearman correlations, age- and medication-adjusted sensitivity analysis, independent training cohort
- Mass spectrometry-based proteomics
- FDR-corrected Spearman correlations
- Age- and medication-adjusted sensitivity analysis
- Independent training cohort
Main finding
As reported in the abstract
Proteins associated with ≥1 fitness variable
35
Remained significant after age- and medication-adjusted sensitivity analysis
21
Proteins correlated with both VO2peak and muscle strength
9
Proteins (PON3), IGF1, CRISP3, COL6A3, C3 showed the largest, most consistent effect sizes and associations with central adiposity, blood lipids, blood pressure and insulin resistance
5 proteins
Observational data: associations, not effects.
Further findings
Markers across four fitness-level groups
- IGF1, PON3 and PRG4 identified as markers of higher overall fitness
Exercise responsiveness in independent cohort of untrained men (6 weeks supervised aerobic training, n = 28)
- Fitness-associated proteins changed after aerobic training without significant weight-loss
- 9
Original publication
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