Gestational diabetes & diabetes in pregnancy
Relationships Between Regional and Ectopic Adiposity and Insulin Sensitivity in Early and Late Pregnancy
Authors' conclusion
Insulin resistance in early pregnancy is strongly associated with total, regional, and ectopic adiposity. However, in late pregnancy, factors other than regional and ectopic adiposity predominately influence insulin sensitivity. Prepregnancy weight categories proportionately alter gestational weight gain, adiposity distribution, and glucometabolic responses.
Study context
- Population
- Pregnant women of varying prepregnancy weights
- Participants
- 59 vs 47
- Exposure
- Early pregnancy vs Late pregnancy
- Early pregnancyn = 59
- Late pregnancyn = 47
- Outcome
- Correlations of adiposity with insulin sensitivity
Methodological detailshyperinsulinemic-euglycemic clamp
- Hyperinsulinemic-euglycemic clamp
Main finding
As reported in the abstract
- Early pregnancy: Rd inversely correlated with BMI, fat mass (FM), subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), IHL, IMCL and free fatty acid (FFA)
- P values <0.05
- Early pregnancy: Hepatic insulin sensitivity index (HISI) inversely correlated with BMI, FM, SAT, VAT, IMCL and FFA but not with IHL
- P values <0.05
Observational data: associations, not effects.
Further findings
Early-pregnancy IHL and late-pregnancy insulin sensitivity
- Early-pregnancy IHL did not predict late-pregnancy insulin sensitivity
Prepregnancy obesity vs normal prepregnancy weight
- Women with prepregnancy obesity were more insulin resistant but gained less gestational weight, VAT and SAT, and had less decline in insulin sensitivity than normal-weight women
Original publication
Relationships Between Regional and Ectopic Adiposity and Insulin Sensitivity in Early and Late Pregnancy. Diabetes Care. Published 26 February 2026. doi:10.
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