Gestational diabetes & diabetes in pregnancy
Maternal pre-pregnancy BMI differentially regulates intracellular pH in human umbilical vein endothelium from gestational diabetes mellitus pregnancies, with alkalinisation-associated reduction of adenosine transport in normal weight pregnancies
Authors' conclusion
Pre-pregnancy maternal metabolic status influences endothelial adaptation or maladaptation to GDM. Stratifying GDM cases by pre-pregnancy maternal BMI uncovers subgroup-specific physiological responses, highlighting the importance of tailored approaches in understanding GDM pathophysiology.
Study context
- Population
- HUVECs from women with normal pregnancies or type A1 gestational diabetes mellitus (GDM), stratified by maternal pre-pregnancy BMI into normal weight, overweight and obesity subgroups
- Participants
- 23 vs 43
- Comparison
- HUVECs from GDM vs normal pregnancies, stratified by pre-pregnancy BMI
- GDMn = 23
- Normal pregnanciesn = 43reference
- Outcome
- NHE1-dependent pHi regulation and its impact on human equilibrative nucleoside transporter-mediated adenosine transport
Methodological detailsin vitro, stratified by maternal pre-pregnancy BMI (normal weight, overweight, obesity)
- In vitro
- Stratified by maternal pre-pregnancy BMI (normal weight, overweight, obesity)
Main finding
As reported in the abstract
Intracellular alkalinisation with GDM vs normal pregnancies
≈0.6 pHi units
Increased pHi recovery in GDM with pre-pregnancy overweight
≈3.8-fold
Increased NHE1 activity in GDM with pre-pregnancy overweight
≈4.8-fold
Original publication
Maternal pre-pregnancy BMI differentially regulates intracellular pH in human umbilical vein endothelium from gestational diabetes mellitus pregnancies, with alkalinisation-associated reduction of adenosine transport in normal weight pregnancies. Diabetologia. Published 24 February 2026. doi:10.
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