Pre‐conception weight loss interventions in women with polycystic ovary syndrome and the effect on perinatal outcomes: A quantitative synthesis of surrogate outcomes
Authors' conclusion
Limited data on antenatal outcomes highlight a knowledge gap amongst a group at high perinatal risk.
Study context
- Population
- Women with polycystic ovary syndrome (PCOS) and body mass index (BMI) ≥25 kg/m²37 randomised controlled trials (RCTs)
- Comparison
- Pre-conception weight loss interventions vs standard care
- Outcome
- Pregnancy rates, live births and miscarriages
Methodological detailsLimitations: outcome measure and intervention heterogeneity, inconsistent definitions, low use of core outcome sets
- Limitations: outcome measure and intervention heterogeneity, inconsistent definitions, low use of core outcome sets
Pooled result
As reported in the abstract
Pregnancy rate (one study) · 12-month lifestyle intervention
Lifestyle intervention
23.3%-26.7%
Standard care
16.7%
Further pooled results
| Outcome | Reduction (kg/m²) (CI) | |
|---|---|---|
| BMIQuantitative meta-analysis | −0.34 (−0.65 to −0.02) | |
| −1−0.500.5Difference, kg/m² (linear scale) |
Original publication
Pre‐conception weight loss interventions in women with polycystic ovary syndrome and the effect on perinatal outcomes: A quantitative synthesis of surrogate outcomes. Diabetes Obes Metab. Published 1 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →