Shared and divergent acute cardiovascular risk protein responses to lipid infusion in women with and without polycystic ovary syndrome (PCOS)
Authors' conclusion
Acute lipid infusion revealed shared and phenotype-specific proteomic responses linked to early vascular stress. In PCOS, persistent dysregulation suggests reduced metabolic adaptability, with exploratory signals that may complement established biomarkers of early cardiovascular risk.
Study context
- Population
- Healthy control women and women with PCOS10 healthy control (HC), 12 PCOS · Healthy control women 10 · women with PCOS 12
- Comparison
- Intralipid vs saline infusion, in HC women and women with PCOS
- Primary endpoint
- Plasma CVRP expression (SOMAscan proteomics)
- Follow-up
- Baseline, post-lipid (180 min) and post-clamp (300 min)
Methodological detailscross-over, hyperinsulinemic-euglycemic clamp, SOMAscan proteomics
- Cross-over
- Hyperinsulinemic-euglycemic clamp
- SOMAscan proteomics
Primary result
As reported in the abstract
CVRP expression after lipid infusion, HC · post-lipid (180 min)
- Cardiovascular risk proteins (CVRPs) altered by lipid infusion in HC
- 11 out of 54
- Increased in HC: RANK, IL2RA, TACI, SLAF5, DCN
- p <0.05
- Decreased in HC: THPO, BOC, SOD2, FGF23, AgRP
- p <0.05
Further findings
CVRP responses in PCOS
- Responses mirrored HC except lower AgRP following lipid infusion
- P < 0.01
- Persistent elevation of SLAF5 and DCN following insulin in PCOS
- P < 0.05
Enrichment analysis
- Altered proteins linked to immune activation, cell proliferation and cytokine-receptor signalling
Original publication
Shared and divergent acute cardiovascular risk protein responses to lipid infusion in women with and without PCOS. Diabetes Obes Metab. Published 29 September 2025. doi:10.
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