Sex Steroids and Women’s Physical Performance in Midlife: Findings From the Menarche-To-PreMenopause Study
Authors' conclusion
Findings from this study suggest that E1 was negatively associated with chair rise performance, whereas DHT and SHBG concentrations were positively associated with standing balance performance among Australian women in their 40s. While sex steroids seem to be closely related to performance, other factors, such as age and body size, may influence those associations.
Study context
- Population
- Middle-aged Australian women aged 44.6 ± 1.6 years from the Menarche-to-PreMenopause Study
- Participants
- 484 women
- Outcome
- Associations of log-transformed sex steroids and SHBG with physical performance (handgrip strength, chair rise, standing balance)
Methodological detailsEstrogens and androgens measured by liquid chromatography-mass spectrometry; Sex hormone-binding globulin (SHBG) by immunoassays
- Estrogens and androgens measured by liquid chromatography-mass spectrometry; SHBG by immunoassays
Main finding
As reported in the abstract
Estrone (E1) vs chair rise performance (linear regression; negative association), fully adj. coef.
−0.2
95% CI −0.3 to −0.002
Higher DHT: 30% lower odds of worse standing balance (logistic regression)
95% CI, 0.6-0.9
Higher SHBG: 30% lower odds of worse standing balance (logistic regression)
95% CI, 0.5-0.9
Observational data: associations, not effects.
Original publication
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