Polycystic Ovary Syndrome and Sleep Disturbance in Postmenopausal Women: Study of Women’s Health Across the Nation
Authors' conclusion
Longitudinal patterns of sleep disturbances differ between those with and without PCOS. In women with PCOS the prevalence of sleep disturbance remained relatively stable into postmenopause rather than increasing.
Study context
- Population
- Women in the Study of Women's Health Across the Nation (SWAN), followed into postmenopause
- Participants
- 83 vs 1,977
- Comparison
- Women with polycystic ovary syndrome (PCOS) vs without PCOS
- PCOSn = 83
- Without PCOSn = 1,977reference
- Primary endpoint
- Longitudinal changes in self-reported sleep disturbances (trouble falling asleep, waking several times at night, waking earlier than planned); actigraphic and self-reported sleep measures at visit 15
- Follow-up
- Baseline to 15th visit (20-22 years from start of study)
Methodological detailslongitudinal and cross-sectional analyses
- Longitudinal and cross-sectional analyses
Primary result
As reported in the abstract
Self-reported sleep disturbance (longitudinal) · baseline to visit 15
- Sleep disturbance prevalence plateaued with PCOS, whereas it increased through postmenopause without PCOS
- In adjusted longitudinal analyses, naturally postmenopausal women with PCOS were significantly less likely to report sleep disturbances vs without PCOS
- Adjusted
Further findings
Actigraphic and self-reported sleep measures · visit 15
- Sleep measures did not differ between PCOS and without PCOS
Original publication
Polycystic Ovary Syndrome and Sleep Disturbance in Postmenopausal Women: Study of Women’s Health Across the Nation. J Clin Endocrinol Metab. Published 25 September 2025. doi:10.
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