Serum Antimüllerian Hormone as a Biomarker of Functional Testicular Reserve: A Comparative Analysis
Authors' conclusion
AMH reflects Sertoli cell function and testicular status rather than directly influencing spermatogenesis, potentially serving as a complementary male fertility biomarker.
Study context
- Population
- White European, non-Finnish men with confirmed fertility, primary infertility or nonobstructive azoospermia (NOA); hormonal and semen analyses per WHO 2010 criteria
- Participants
- 1,085 participants
- Exposure
- Serum antimüllerian hormone (AMH) in men with NOA vs primary infertility vs confirmed fertility
- Fertilen = 116reference
- Primary infertilityn = 791
- NOAn = 178
- Outcome
- Serum AMH levels across fertility statuses
Methodological detailsCross-sectional design limits causality; limited ethnic generalizability
- Cross-sectional design limits causality; limited ethnic generalizability
Main finding
As reported in the abstract
Serum AMH
P less than .001
Observational data: associations, not effects.
Further findings
Correlations of AMH (Spearman)
- AMH correlated negatively with age and follicle-stimulating hormone (FSH)
- AMH correlated positively with testicular volume and sperm concentration
Multivariable linear regression
- Age, FSH and testicular volume independently associated with AMH
- FSH and testicular volume, not AMH, independently associated with sperm concentration
Original publication
Serum Antimüllerian Hormone as a Biomarker of Functional Testicular Reserve: A Comparative Analysis. J Clin Endocrinol Metab. Published 22 September 2025. doi:10.
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