Reproductive factors, insulin resistance surrogate indices, and circadian syndrome among middle-aged and elderly women a mediation analysis using two-national cohorts
Authors' conclusion
Significant inverse relationships were observed between early age at menarche/menopause and increased CircS risk, with IR largely mediating these associations.
Study context
- Population
- Middle-aged and elderly women without circadian syndrome at baseline, China Health and Retirement Longitudinal Study (CHARLS) (China) and English Longitudinal Study on Aging (ELSA) (England)
- Exposure
- Reproductive factors (age at menarche, menopause) and incident circadian syndrome, mediated by insulin resistance (IR) indices
- Outcome
- Incident circadian syndrome (CircS)
Methodological detailstwo national cohorts, training set (CHARLS) and validation set (ELSA)
- Two national cohorts
- Training set (CHARLS) and validation set (ELSA)
Main finding
As reported in the abstract
New-onset CircS in CHARLS
465
15.94%
New-onset CircS in ELSA
291
11.89%
Triglyceride glucose (TyG), triglyceride glucose-waist to height ratio (TyG-WHtR), triglyceride glucose-waist circumference (TyG-WC), lipid accumulation product (LAP), Chinese visceral adiposity index (CVAI) and estimated glucose disposal rate (eGDR) mediated the menarche-CircS association; share of mediating effect by TyG-WHtR
14.3%
Observational data: associations, not effects.
Further findings
TyG-WHtR cutoff for predicting CircS, early menarche
- TyG-WHtR cutoff
- 4.507
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →