Longitudinal associations of dietary intake, physical activity, and short-chain fatty acids with bone development in early postmenopausal women
Authors' conclusion
These findings suggest that specific dietary components and gut microbiota-derived metabolites may play a role in maintaining bone health during early postmenopause and highlight the need for further investigation into their preventive and therapeutic potential.
Study context
- Population
- Early postmenopausal Swedish women aged 50–60 years
- Participants
- 223 women
Methodological details2-year longitudinal study, linear mixed models for repeated measures
- 2-year longitudinal study
- Linear mixed models for repeated measures
Primary result
As reported in the abstract
Associations of diet, physical activity and short-chain fatty acids (SCFAs) with bone outcomes (total hip BMD, tibial vBMD, microarchitecture by DXA and high-resolution peripheral quantitative computed tomography (HR-pQCT)) · baseline, 1 year and 2 years
- Higher baseline fiber intake positively associated with trabecular bone volume fraction
- Total fat inversely associated with total hip bone mineral density (BMD), total volumetric BMD (vBMD) and cortical area
- Greater energy intake during follow-up positively associated with cortical area
- No associations between bone characteristics and calcium or vitamin D intake
- Baseline transport-related and changes in domestic/gardening activity inversely associated with bone measurements
- Baseline acetic, formic and isovaleric acid positively associated with bone outcomes; changes in caproic acid negatively associated
Original publication
Longitudinal associations of dietary intake, physical activity, and short-chain fatty acids with bone development in early postmenopausal women. Osteoporos Int. Published 2 February 2026. doi:10.
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