Associations between body composition and bone loss in early postmenopausal women
Study context
- Population
- Swedish women aged 50–60, within 1–4 yr postmenopause, followed for 2 yr
- Participants
- 223 women
- Primary endpoint
- Associations between body composition (body weight, ALM, fat mass by DXA) and bone outcomes (areal BMD at TH, FN, LS by DXA; tibia microarchitecture and vBMD by HR-pQCT)
- Follow-up
- 2 yr
Methodological detailscross-sectional and longitudinal analyses, linear mixed models for repeated measures
- Cross-sectional and longitudinal analyses
- Linear mixed models for repeated measures
Primary result
As reported in the abstract
Associations of body composition with bone outcomes
- Higher baseline body weight, BMI, fat mass and appendicular lean mass (ALM) significantly associated with greater cortical area, cortical volumetric BMD (vBMD) and total vBMD
- Baseline body weight, BMI and fat mass, but not ALM, positively associated with TH BMD
- Longitudinally, increases in ALM significantly associated with favorable changes in TH BMD, LS BMD, total vBMD, trabecular bone volume fraction and cortical area
- Changes in body weight and BMI associated with multiple bone outcomes; fat mass change linked only with cortical area
Further findings
Exploratory group comparison: low baseline fat mass (28.14%) and greater ALM loss (∆% ALM: −2.87 kg) vs high fat mass and maintained ALM
- Greater reduction in TH BMD
- 2.4-fold
- Greater reduction in tibia total vBMD
- 5.2-fold
- Exploratory
Original publication
Associations between body composition and bone loss in early postmenopausal women. J Bone Miner Res. Published 11 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →