Associations between body composition and the risk of fracture according to bone mineral density in postmenopausal women: a population-based database cohort study
Authors' conclusion
General obesity and central obesity are not protective against any fracture, VF and HF in postmenopausal women with osteopenia or osteoporosis.
Study context
- Population
- Postmenopausal women aged 66 years, National Screening Program for Transitional Ages database
- Exposure
- Body mass index (BMI) and waist circumference (WC) categories, stratified by BMD
- Outcome
- Newly diagnosed fracture (ICD-10 codes)
- Follow-up
- 7.7 ± 1.4 years
Methodological detailsdatabase cohort, stratified by bone mineral density
- Database cohort
- Stratified by bone mineral density
Main finding
As reported in the abstract
Fracture
Any fracture
41 672
17.9%
Vertebral fractures
20 326
8.7%
Hip fractures
2883
1.2%
Observational data: associations, not effects.
Further findings
Vertebral fracture by BMI/WC in osteoporosis
| aHR (95% CI) | ||
|---|---|---|
| Severely obese, osteoporosisHighest aHR | 3.45 (2.99–3.97) | |
| WC ≥ 95 cm, osteoporosisHighest aHR | 4.79 (4.09–5.60) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Hip fracture by BMI/WC
| aHR (95% CI) | ||
|---|---|---|
| Underweight, osteopeniaHighest aHR | 1.94 (1.16–3.27) | |
| Underweight, osteoporosisHighest aHR | 2.96 (2.15–4.10) | |
| WC ≥ 95 cm | 2.80 (1.91–4.91) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Original publication
Associations between body composition and the risk of fracture according to bone mineral density in postmenopausal women: a population-based database cohort study. Eur J Endocrinol. Published 23 November 2023. doi:10.
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