Proposed diagnostic criteria for the diagnosis of hypophosphatasia in children and adolescents: results from the hypophosphatasia (HPP) International Working Group
Authors' conclusion
These were organized into three major and six minor criteria, with diagnosis of HPP being made when two major or one major and two minor criteria are present.
Study context
- Population
- Published literature on diagnosis or clinical manifestations of HPP in children (narrative reviews, case series/reports)papers reviewed
- Participants
- 93 participants
- Outcome
- Agreement and prevalence of 15 initial clinical manifestations in the literature
Methodological detailsproposed diagnostic criteria, International HPP Working Group, multidisciplinary experts from Europe and North America, two independent reviewers, Medline, Medline In-Process and Embase search 2005–2020
- Proposed diagnostic criteria
- International HPP Working Group
- Multidisciplinary experts from Europe and North America
- Two independent reviewers
- Medline, Medline In-Process and Embase search 2005–2020
Recommendations
As reported in the abstract
Proposed criteria: diagnosis of HPP when 2 major or 1 major + 2 minor criteria present
3 major and 6 minor criteria
Original publication
Proposed diagnostic criteria for the diagnosis of hypophosphatasia in children and adolescents: results from the HPP International Working Group. Osteoporos Int. Published 20 November 2023. doi:10.
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