The challenge of hypophosphatasia diagnosis in adults: results from the hypophosphatasia (HPP) International Working Group Literature Surveillance
An erratum to this article was published (Osteoporos Int, May 2024 ↗)
Authors' conclusion
Authors suggested the integrated use of the identified major and minor diagnostic criteria, which either includes two major criteria, or one major criterion and two minor criteria, for the diagnosis of HPP in adults.
Study context
- Population
- Papers explicitly addressing the diagnosis of HPP in adults, and patients included in these studies119 papers
- Outcome
- Pooled prevalence of 17 diagnostic characteristics
Methodological detailsliterature surveillance, Medline, Medline In-Process and Embase search, expert working group consensus
- Literature surveillance
- Medline, Medline In-Process and Embase search
- Expert working group consensus
Recommendations
As reported in the abstract
Pooled prevalence of diagnostic characteristics
Diagnostic findings with pooled prevalence over 50%, considered as major diagnostic criteria
6
Major diagnostic criteria finally defined for HPP in adults
4
Minor diagnostic criteria finally defined for HPP in adults
5
Original publication
The challenge of hypophosphatasia diagnosis in adults: results from the HPP International Working Group Literature Surveillance. Osteoporos Int. Published 20 November 2023. doi:10.
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