Association between osteoporosis and risk of dementia: a Korean women nationwide population-based cohort study
Main finding · All-cause dementiaResult — go to the resultAdjusted subdistribution hazard ratio 1.14 95% CI 1.08–1.21Authors' conclusion
Our findings highlight an association between osteoporosis and increased risks of developing all-cause dementia, AD dementia, and VaD.
Study context
- Population
- Dementia-free 66-year-old Korean women in the National Screening Program for Transitional Ages, 2010–2011mean follow-up 10.4 ± 1.8 years
- Participants
- 131,872 participants
- Exposure
- Osteoporosis and osteopenia vs normal spine BMD T-score
- Outcome
- Incident all-cause dementia, including Alzheimer's disease (AD) dementia and vascular dementia
- Follow-up
- Until 2021
Methodological detailsnationwide population-based, health-screening cohort, Fine-Gray subdistribution hazard models with death as competing risk
- Nationwide population-based
- Health-screening cohort
- Fine-Gray subdistribution hazard models with death as competing risk
Main finding
All-cause dementia
Adjusted subdistribution hazard ratio
1.14
95% CI 1.08–1.21
P < 0.001
Osteoporosisvs Normal
asHR 1.14 (95% CI 1.08–1.21); P < 0.001
As reported in the abstract
- All-cause dementia, whole cohort
- 9399 (7.1%)
Observational data: associations, not effects.
Further findings
| Outcome | asHR (95% CI) | P value | |
|---|---|---|---|
| AD dementiaOsteoporosisvs Normal | 1.14 (1.08–1.22) | P < 0.001 | |
| Vascular dementiaOsteoporosisvs Normal | 1.42 (1.08–1.87) | P = 0.013 | |
| 0.512Adjusted subdistribution hazard ratio (log scale) |
Original publication
Association between osteoporosis and risk of dementia: a Korean women nationwide population-based cohort study. Osteoporos Int. Published 24 July 2025. doi:10.
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