Parathyroidectomy Restores Muscle Strength and Transcriptome in Individuals With Primary Hyperparathyroidism
Authors' conclusion
These findings highlight the impact of parathyroidectomy on skeletal muscle function and suggest that muscle assessments should be included in surgical referral criteria to address age-related muscle decline and improve long-term outcomes.
Study context
- Population
- Postmenopausal women with PHPT planned for surgery, no disabling comorbidities; Karolinska University Hospital, Stockholm, Sweden15 completed
- Participants
- 21 women
- Exposure
- Before vs after parathyroidectomy
- Outcome
- Functional and molecular changes in skeletal muscle before and after parathyroidectomy
Methodological detailsbefore-and-after, Conducted spring and fall of 2023
- Before-and-after
- Conducted spring and fall of 2023
Main finding
As reported in the abstract
- Normalized calcium levels
- P < .001
- Improved muscle strength
- P < .005
- Muscle volume increased
- P = .023
- Fat fraction reduced
- P = .013
- Differentially expressed genes postsurgery, enriched in pathways mirroring exercise-induced adaptations
- 981
Observational data: associations, not effects.
Original publication
Parathyroidectomy Restores Muscle Strength and Transcriptome in Individuals With Primary Hyperparathyroidism. J Clin Endocrinol Metab. Published 22 July 2025. doi:10.
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