Increasing incidence and prevalence of biochemically confirmed primary hyperparathyroidism in Stockholm, 2006-2020
Authors' conclusion
Using a large healthcare database, we observed substantially increasing PHPT incidence and prevalence, predominantly in older individuals. Only 52% received clinical diagnosis
Study context
- Population
- Adults aged ≥20 years with paired calcium and parathyroid hormone (PTH) measurements meeting biochemical criteria for primary hyperparathyroidism (PHPT), Stockholm Region, Sweden, 2006–2020; excluded eGFR ≤30 mL/min/1.73 m², secondary hyperparathyroidism or prior parathyroid surgerybiochemical PHPT
- Participants
- 10,190 adults
- Outcome
- Annual incidence rate and point prevalence of biochemically confirmed PHPT
Methodological detailsprespecified biochemical diagnostic algorithms
- Prespecified biochemical diagnostic algorithms
Main finding
As reported in the abstract
Incidence and prevalence of biochemically confirmed PHPT · 2009 to 2020
Age- and sex-adjusted incidence rate, 2009
2.81 per 10 000 person-years (95% CI 2.55-3.09)
Age- and sex-adjusted incidence rate, 2020
4.28 per 10 000 person-years (95% CI 3.98-4.59)
Prevalence, start
0.35 per 1000 individuals
Prevalence, end
4.76 per 1000 individuals
Observational data: associations, not effects.
Further findings
Ionized calcium
- Median ionized calcium
- 1.39 mmol/L
Clinical recognition and surgical management
- Clinical diagnosis of PHPT documented
- 5346 (52%)
- Parathyroidectomy among clinically diagnosed
- 2800 (52%)
- Surgery rates after 2013, annually
- 4% to 5%
Original publication
Increasing incidence and prevalence of biochemically confirmed primary hyperparathyroidism in Stockholm, 2006-2020. J Clin Endocrinol Metab. Published 11 April 2026. doi:10.
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