Carotid Intima-Media Thickness in Surgically or Conservatively Managed Patients With Primary Hyperparathyroidism
Authors' conclusion
Our results suggest that in postmenopausal patients with PHPT, subclinical atherosclerosis could be halted by PTx, whereas it worsens over time in nonoperated patients with milder disease.
Study context
- Population
- Consecutive postmenopausal patients with primary hyperparathyroidism (PHPT)
- Participants
- 52 patients
- Exposure
- Parathyroidectomy vs conservative management
- PTxn = 22
- non-PTxn = 30reference
- Outcome
- Change in carotid intima-media thickness (IMT)
- Follow-up
- ≥ 24 months after surgery or conservative management
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Carotid IMT, baseline to follow-up · ≥ 24 months
PTx: Intima-media thickness (IMT) did not significantly vary after surgery (mm, P = .366)
0.85 ± 0.14 to 0.89 ± 0.22
non-PTx: IMT significantly increased, even adjusting for BP (mm, P = .008)
0.80 ± 0.18 to 0.93 ± 0.23
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Follow-up durationLonger in PTx | P = 0.004 |
Plaque prevalence and incidence
- Did not significantly differ in the 2 groups
Cardiovascular (CV) risk factors · follow-up
- Systolic and diastolic BP increased in both groups; other CV risk factors did not significantly vary
PHPT parameters · ≥ 24 months
- Significantly improved after PTx; in non-PTx serum phosphate slightly decreased and PTH increased
Original publication
Carotid Intima-Media Thickness in Surgically or Conservatively Managed Patients With Primary Hyperparathyroidism. J Clin Endocrinol Metab. Published 12 February 2024. doi:10.
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