Potential risk factors for mild cognitive impairment among patients with type 2 diabetes experiencing hypoglycemia
Authors' conclusion
Hypoglycemia increased MCI risk among patients with T2DM. Low grip strength, DR, and multiple hypoglycemia episodes may be potential risk factors for hypoglycemia-associated MCI.
Study context
- Population
- Patients with T2D screened in 2019 and followed up in 2022
- Participants
- 328 patients
- Exposure
- Hypoglycemia vs no hypoglycemia
- Outcome
- MCI (Montreal Cognitive Assessment (MoCA); established criteria)
- Follow-up
- 3 years
Main finding
MCI
Relative risk
2.221
95 % CI 1.269–3.885
As reported in the abstract
Observational data: associations, not effects.
Further findings
Risk factors for mild cognitive impairment (MCI) in patients with hypoglycemia (multivariate logistic analysis)
- Grip strength, aOR
- 0.909 (95 % CI 0.859-0.963)
- Existing diabetic retinopathy (DR), aOR
- 3.078 (95 % CI 1.158-12.358)
- Multiple hypoglycemia episodes, aOR
- 4.642 (95 % CI 1.284-16.776)
- All P < 0.05
- Low grip strength, DR and multiple episodes associated with higher odds of MCI
Original publication
Potential risk factors for mild cognitive impairment among patients with type 2 diabetes experiencing hypoglycemia. Diabetes Res Clin Pract. Published 2 December 2023. doi:10.
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