Polycystic Ovary Syndrome, Metabolic Syndrome, and Inflammation in the Hispanic Community Health Study/Study of Latinos
Main finding · MetSResult — go to the resultOdds ratio 1.41 95% CI 1.13–1.76Authors' conclusion
Hispanic/Latino females with PCOS had higher odds of MetS, IFG, and elevated TGL than their peers without PCOS. Interaction analyses revealed that the odds of MetS are higher among PCOS females who have premenopausal status or high inflammation. Interventions in Hispanic/Latinas should target these outcomes for effective management of the disease.
Study context
- Population
- US Hispanic/Latino females, ages 23–82 years, visit 2 of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
- Participants
- 7,316 females
- Exposure
- Polycystic ovary syndrome (PCOS) vs no PCOS
- Outcome
- Metabolic syndrome (MetS)
Methodological detailsmulticenter, observational, secondary analysis of HCHS/SOL visit 2
- Multicenter
- Observational
- Secondary analysis of HCHS/SOL visit 2
Main finding
MetS
Odds ratio
1.41
95% CI 1.13–1.76
PCOSvs No PCOS
OR 1.41 (95% CI 1.13–1.76)
As reported in the abstract
- PCOS prevalence
- 18.8%
Observational data: associations, not effects.
Further findings
| Outcome | OR (CI) | |
|---|---|---|
| Impaired fasting glucose (IFG) | 1.42 (1.18–1.72) | |
| Elevated TG | 1.48 (1.20–1.83) | |
| MetS, adjusted for superadditive CRP-PCOS interactionAttenuated effect | 1.29 (0.93–1.78) | |
| 0.512Odds ratio (log scale) |
| Outcome | OR | P value |
|---|---|---|
| MetS, effect modification by menopausal statusPCOS vs No PCOS · premenopausal | 1.46 | Pint= .02 |
| MetS, effect modification by menopausal statusPCOS vs No PCOS · postmenopausal | 1.34 | Pint= .06 |
| MetS, effect modification by CRPPCOS vs No PCOS · elevated CRP | 1.41 | Pint= .04 |
| MetS, effect modification by CRPPCOS vs No PCOS · normal CRP | 1.26 | Pint= .16 |
Original publication
Polycystic Ovary Syndrome, Metabolic Syndrome, and Inflammation in the Hispanic Community Health Study/Study of Latinos. J Clin Endocrinol Metab. Published 18 June 2024. doi:10.
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