Gestational Age-specific Reference Intervals for Androgens in Pregnancy
Authors' conclusion
The study highlights a methodology for constructing gestational age-specific TT, A4, and 17-OHP levels to provide a better interpretation of results in a cohort of healthy Chinese women. The observation in PE supports previous findings, and the higher levels of TT, A4, and 17-OHP were observed before the onset of PE.
Study context
- Population
- Healthy Chinese pregnant women
- Participants
- 600 women
- Outcome
- Gestational age-specific reference intervals of TT, A4 and 17-OHP
Methodological detailspopulation-based, longitudinal serum sampling across gestation, LC-MS/MS measurement, multilevel modeling
- Population-based
- Longitudinal serum sampling across gestation
- LC-MS/MS measurement
- Multilevel modeling
Main finding
As reported in the abstract
Androgen levels across gestation
Correlation of A4 with total testosterone (TT)
R = .90, P = <.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| A4, TT and 17-OHP in PE vs non-PESignificantly higher levels of A4, TT and 17-OHP with PE | P ≤ 0.01 |
A4, TT and 17-OHP by fetal sex
- Mothers carrying male vs female fetuses had comparable levels of A4, TT and 17-OHP
Original publication
Gestational Age-specific Reference Intervals for Androgens in Pregnancy. J Clin Endocrinol Metab. Published 13 June 2024. doi:10.
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