Polycystic Ovarian Morphology and Chronic Morbidity and Mortality in Polycystic Ovary Syndrome (PCOS)
Authors' conclusion
In this study, the PCOM pattern was associated with early metabolic abnormalities and increased risk of type 2 diabetes but not with increased mortality or other chronic diseases.
Study context
- Population
- Women with PCOS and baseline sonographic data, enrolled 1987–2005 at a single academic referral center, follow-up until 2024of 1089 enrolled
- Participants
- 340 women
- Exposure
- PCOM vs non-PCOM
- PCOMn = 189
- non-PCOMn = 151reference
- Outcome
- All-cause mortality and chronic morbidity (diabetes, cardiovascular, neurologic, thyroid, respiratory, gastrointestinal, kidney, autoimmune, psychiatric, cancer conditions)
- Follow-up
- In older age
Methodological detailssingle academic referral center, 37-year follow-up, Data analyzed January to April 2024
- Single academic referral center
- 37-year follow-up
- Data analyzed January to April 2024
Main finding
Non-insulin-dependent diabetes
Adjusted odds ratio
2.92
95% CI 1.06–2.82
P = 0.02
Events by group
As reported in the abstract
Observational data: associations, not effects.
Further findings
Age at death
P = 0.08
Follow-up duration
P < 0.001
Baseline LH · enrollment
P < 0.001
Baseline total testosterone · enrollment
P < 0.001
Baseline fasting insulin · enrollment
P < 0.001
Baseline triglycerides · enrollment
P < 0.001
Mean
| Outcome | PCOM | non-PCOM | P value |
|---|---|---|---|
| Baseline BMI · enrollment | 27.20 (SD 5.74) | 25.31 (SD 6.31) | P = 0.004 |
Original publication
Polycystic Ovarian Morphology and Chronic Morbidity and Mortality in PCOS. JAMA Netw Open. Published 1 October 2025. doi:10.
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