Plasma Metabolite Associations for Risk and Laboratory Measures of Type 2 Diabetes in a Large-Scale Finnish Prospective Cohort
Authors' conclusion
This study identifies T2D plasma metabolic biomarkers for further investigation in women and other populations. The findings enhance our understanding of T2D biology.
Study context
- Population
- Finnish men in the Metabolic Syndrome in Men (METSIM) study; 1,412 with prevalent T2D, 1,234 developed incident T2D
- Participants
- 10,163 Finnish men
- Outcome
- Associations of 979 named metabolites with prevalent T2D
- Follow-up
- Baseline
Methodological detailsmetabolomic profiling, exploratory mediation analysis, exploratory predictive models
- Metabolomic profiling
- Exploratory mediation analysis
- Exploratory predictive models
Main finding
As reported in the abstract
Plasma metabolites associated with prevalent T2D
Metabolites significantly associated with prevalent T2D
193
Previously unreported
71
Observational data: associations, not effects.
Further findings
Association with incident T2D · average follow-up 13.6 years
- Of the 193 metabolites, associated with incident T2D
- 88
Associations with T2D-related laboratory measures in prevalent T2D
- Number of laboratory measures associated per metabolite
- zero to 24 (mean 10.2)
Mediation of risk factor–T2D onset associations
- Metabolites partially mediating associations of the five risk factors with T2D onset
- 81
- Under standard mediation assumptions
- Exploratory
Prediction of incident T2D
- Significant metabolites showed improved predictive ability for future T2D
- Exploratory
Original publication
Plasma Metabolite Associations for Risk and Laboratory Measures of Type 2 Diabetes in a Large-Scale Finnish Prospective Cohort. Diabetes Care. Published 4 February 2026. doi:10.
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