Plasma metabolite association profiles for type 2 diabetes genetic clusters in Finnish men
Authors' conclusion
This study underscores the value of type 2 diabetes clustering and highlights metabolic heterogeneity across clusters.
Study context
- Population
- Finnish men with 979 named plasma metabolites measured (Metabolon HD4 mass spectrometry platform)
- Participants
- 10,015 men
- Outcome
- Metabolite associations with T2D overall and cluster-partitioned PRSs
Methodological detailspolygenic risk scores, mediation analysis
- Polygenic risk scores
- Mediation analysis
Performance
As reported in the abstract
Metabolite–PRS associations
Metabolites significantly associated with T2D genetic risk
337
Exclusive to cluster-partitioned polygenic risk scores (PRSs)
242
Significant metabolites with significantly heterogeneous associations across clusters
26
Metabolic pathways significantly enriched among cluster-associated metabolites
33
Further findings
Mediation of PRS–incident T2D association by metabolites · mean 13.6 years' follow-up
- Associated metabolites showing patterns statistically consistent with a mediating role
- >50%
Original publication
Plasma metabolite association profiles for type 2 diabetes genetic clusters in Finnish men. Diabetologia. Published 18 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →