Plasma fatty acid esters of hydroxy fatty acids and surrogate fatty acid esters of hydroxy fatty acids hydrolysis activity in children with or without obesity and in adults with or without coronary artery disease
Authors' conclusion
Altered FAHFA metabolism is associated with obesity and MI, and inhibition of FAHFA hydrolysis should be studied further as a possible therapeutic strategy in obesity and MI.
Study context
- Population
- Children with or without obesity and adults with or without coronary artery disease (CAD)
- Participants
- 20 / 40 / 10 / 28
- Exposure
- Children with vs without obesity; adults with vs without CAD
- Children without obesityn = 20reference
- Children with obesityn = 40
- Adults without CADn = 10reference
- Adults with CADn = 28
- Outcome
- Plasma FAHFA levels (palmitic acid hydroxy stearic acid (PAHSA), POHSA, oleic acid hydroxy stearic acid (OAHSA), stearic acid hydroxy stearic acid) and surrogate FAHFA hydrolysis activity (fatty acid (FA)/FAHFA or hydroxy fatty acid (HFA)/FAHFA ratio), by liquid chromatography-tandem mass spectrometry
Main finding
As reported in the abstract
- Children with obesity vs Children without obesity: P = 0.001
- Children with obesity vs Children without obesity: P = 0.006
- Children with obesity vs Children without obesity: P = 0.011
- Children with obesity vs Children without obesity: P = 0.040
- Children with obesity vs Children without obesity: P = 0.025
- Adults with CAD and history of myocardial infarction (MI) vs Adults with CAD without MI: P = 0.026
- Adults with CAD and history of MI vs Adults with CAD without MI: P = 0.041
- Adults with CAD and history of MI vs Adults with CAD without MI: P = 0.003
- Adults with CAD and history of MI vs Adults with CAD without MI: P = 0.038
Observational data: associations, not effects.
Original publication
Plasma fatty acid esters of hydroxy fatty acids and surrogate fatty acid esters of hydroxy fatty acids hydrolysis activity in children with or without obesity and in adults with or without coronary artery disease. Diabetes Obes Metab. Published 29 May 2024. doi:10.
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