A ketogenic diet lowers myocardial fatty acid oxidation but does not affect oxygen consumption: a study in overweight humans
Authors' conclusion
A KD significantly reduced myocardial FFA uptake and oxidation, presumably by increasing ketone body oxidation. However, this change in cardiac substrate utilization did not improve MVO2 , speaking against the thrifty substrate hypothesis.
Study context
- Population
- Individuals with overweight or obesitycrossover
- Participants
- 11 individuals
- Comparison
- Ketogenic diet (KD) vs standard diet
- Primary endpoint
- Myocardial FFA uptake and oxidation and MVO2 (aim)
Methodological detailscrossover, Myocardial free fatty acid (FFA) oxidation, uptake and esterification by dynamic [11 C]palmitate positron emission tomography (PET)/CT; MVO2 and MEE by dynamic [11 C]acetate PET
- Crossover
- Myocardial FFA oxidation, uptake and esterification by dynamic [11 C]palmitate PET/CT; MVO2 and MEE by dynamic [11 C]acetate PET
Primary result
As reported in the abstract
- KD increased plasma β-hydroxybutyrate
- KD vs Standard diet: P < 0.01
- KD vs Standard diet: P = 0.03
- KD vs Standard diet: P = 0.03
- KD vs Standard diet: P = 0.2
Further findings
| Outcome | P value |
|---|---|
| Myocardial external efficiency (MEE)No change in MEE | P = 0.87 |
Original publication
A ketogenic diet lowers myocardial fatty acid oxidation but does not affect oxygen consumption: a study in overweight humans. Obesity (Silver Spring). Published 23 January 2024. doi:10.
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