Three-week Alternate-day Fasting Improves Myocardial Flow Reserve and Reduces Oxygen Use in Overweight Individuals
Authors' conclusion
A 3-week ADF regimen reduced blood pressure and MVO2, and improved MFR, suggesting ADF may provide a nonpharmacological strategy to improve cardiovascular health in individuals with overweight.
Study context
- Population
- Overweight/obese individuals (BMI 32 ± 1.9 kg/m²)completed
- Participants
- 16 individuals
- Comparison
- Alternate-day fasting vs standard diet
Primary result
As reported in the abstract
Myocardial efficiency, perfusion and substrate metabolism after ADF · 3 weeks
MVO2 decreased
10%
P = .01
Total left ventricular energy use decreased
19%
P < .01
Resting myocardial perfusion decreased
9%
P < .05
MFR increased
34%
P < .01
Further findings
Circulating ketones with alternate-day fasting (ADF)
- Peak on fasting days
- 0.67 ± 0.09 mmol/L
- Eating days (remained elevated)
- 0.20 ± 0.03 mmol/L
Blood pressure and cardiac output after ADF
- Systolic/diastolic BP decrease
- 13/9 mmHg (P < .001)
- Cardiac output decrease
- 0.5 L/min (P < .001)
Original publication
Three-week Alternate-day Fasting Improves Myocardial Flow Reserve and Reduces Oxygen Use in Overweight Individuals. J Clin Endocrinol Metab. Published 1 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →