The metabolic load‐capacity model and cardiometabolic health in children and youth with obesity
Authors' conclusion
Participants with unfavourable cardiometabolic profile had higher LCI, suggesting its potential use for predicting and monitoring cardiometabolic health in clinical settings.
Study context
- Population
- Participants aged 10–18 years with obesity (BMI ≥95th); median age 12.5 (IQR 11.1–13.5) years, 43.6% males, 59% mid-late puberty
- Participants
- 39 participants
- Exposure
- High vs low metabolic load-capacity index, sex-specific medians
- Outcome
- Associations between LCI (by ADP: fat mass/fat-free mass; by US: subcutaneous adipose tissue/skeletal muscle thickness) and single and clustered cardiometabolic risk factors (inflammation, insulin resistance, dyslipidemia, hypertension)
Main finding
As reported in the abstract
- Load-capacity index (LCI) by air-displacement plethysmography (ADP) positively associated with markers of inflammation and dyslipidemia
- Higher LCI predicted dyslipidemia in logistic regression
- LCI by ultrasound (US) positively associated with markers of dyslipidemia and blood pressure
- Adjusted for sexual maturation
Observational data: associations, not effects.
Further findings
LCI by US and cardiometabolic markers, mid-late pubertal participants
- LCI by US positively associated with markers of insulin resistance and inflammation
Original publication
The metabolic load‐capacity model and cardiometabolic health in children and youth with obesity. Pediatr Obes. Published 23 January 2024. doi:10.
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