Relationship between metabolic status, physical activity and cardiovascular disease in participants with obesity
Main finding · CVDResult — go to the resultHazard ratio 0.58 95% CI 0.53–0.63Authors' conclusion
Both MHO and any MVPA were associated with reduced risk of CVD in adults with obesity, while PA could modify the relationship between metabolic status and CVD risk.
Study context
- Population
- Adults with obesity free of baseline CVD, enrolled 2006–2010 in the UK Biobank cohort (aged 56 ± 7.9 years)
- Participants
- 109,301 adults
- Exposure
- Metabolically healthy obesity (MHO) vs metabolically unhealthy obesity (MUO), and PA categories
- MHOn = 26,989
- MUOn = 82,312reference
- Outcome
- CVD
- Follow-up
- Median 8.1 years
Methodological detailsUK Biobank, multivariable Cox regression
- UK Biobank
- Multivariable Cox regression
Main finding
As reported in the abstract
Hazard ratio
0.58
95% CI 0.53–0.63
MHOvs MUO
HR 0.58 (95% CI 0.53–0.63)
- CVD events
- 8,059
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CVD by PA among MUO participantsLow PAvs No MVPA | 0.87 (0.81–0.94) | |
| CVD by PA among MUO participantsMedium PAvs No MVPA | 0.85 (0.78–0.93) | |
| CVD by PA among MUO participantsHigh PAvs No MVPA | 0.86 (0.80–0.92) | |
| CVD, joint categoriesMHO & medium PAvs MUO & no MVPALowest CVD risk | 0.45 (0.37–0.56) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Relationship between metabolic status, physical activity and cardiovascular disease in participants with obesity. Int J Obes (Lond). Published 22 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →