Distinguishing health-related parameters between metabolically healthy and metabolically unhealthy obesity in women
Authors' conclusion
Our findings highlight potential additional parameters that should be taken into consideration alongside the commonly used biomarkers for classifying metabolic health in women. These include albumin, urea, total calcium, ferritin, chloride, prolactin, c-peptide, albumin-creatinine ratio, and whole-body mineral density. Moreover, our results also suggest that MHO may represent a transitional phase preceding the development of the MUO phenotype.
Study context
- Population
- Women with obesity referred for bariatric surgery, Endocrinology, Diabetes, and Metabolism Service, São João Hospital and University Centre, Portugal
- Participants
- 182 women
- Exposure
- Metabolically healthy obesity (MHO) vs metabolically unhealthy obesity (MUO)
- Outcome
- Health-related parameters differing between MHO and MUO
Methodological detailssingle-centre, comparative analysis of 50 biomarkers
- Single-centre
- Comparative analysis of 50 biomarkers
Main finding
As reported in the abstract
| Group | Albumin (g/L) | Triglycerides (mg/dL) | Glucose (mg/dL) | HbA1c (%) | Urea (mg/dL) | Total calcium (mEq/L) | Ferritin (ng/mL) | Chloride (mEq/L) | PRL (ng/mL) | Insulin (μU/mL) | C-peptide (ng/mL) | Albumin/creatinine ratio (mg/g creatinine) | Whole-body mineral density (g/cm²) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MHO | 40.1 ± 2.2 | 110.7 ± 51.1 | 99.49 ± 13.0 | 5.58 ± 0.4 | 31.40 ± 10.0 | 4.64 ± 0.15 | 100.04 ± 129.1 | 104.68 ± 1.5 | 13.57 ± 6.3 | 20.36 ± 24.4 | 3.78 ± 1.8 | 15.41 ± 31.0 | 1.27 ± 0.1 |
| MUO | 137.57 ± 82.6 | 119.17 ± 38.9 | 6.15 ± 1.0 | 34.61 ± 10.2 | 4.74 ± 0.17 | 128.55 ± 102.1 | 103.04 ± 2.6 | 12.47 ± 7.1 | 23.87 ± 19.6 | 4.28 ± 1.7 | 48.12 ± 158.7 | 1.23 ± 0.1 |
Albumin (g/L)
MHO40.1 ± 2.2
MUO— not stated in the abstract
Triglycerides (mg/dL)
MHO110.7 ± 51.1
MUO137.57 ± 82.6
Glucose (mg/dL)
MHO99.49 ± 13.0
MUO119.17 ± 38.9
HbA1c (%)
MHO5.58 ± 0.4
MUO6.15 ± 1.0
Urea (mg/dL)
MHO31.40 ± 10.0
MUO34.61 ± 10.2
Total calcium (mEq/L)
MHO4.64 ± 0.15
MUO4.74 ± 0.17
Ferritin (ng/mL)
MHO100.04 ± 129.1
MUO128.55 ± 102.1
Chloride (mEq/L)
MHO104.68 ± 1.5
MUO103.04 ± 2.6
PRL (ng/mL)
MHO13.57 ± 6.3
MUO12.47 ± 7.1
Insulin (μU/mL)
MHO20.36 ± 24.4
MUO23.87 ± 19.6
C-peptide (ng/mL)
MHO3.78 ± 1.8
MUO4.28 ± 1.7
Albumin/creatinine ratio (mg/g creatinine)
MHO15.41 ± 31.0
MUO48.12 ± 158.7
Whole-body mineral density (g/cm²)
MHO1.27 ± 0.1
MUO1.23 ± 0.1
- Between MHO and MUO: P = 0.017
- Between MHO and MUO: P = 0.008
- Between MHO and MUO: P < 0.001
- Between MHO and MUO: P < 0.001
- Between MHO and MUO: P = 0.014
- Between MHO and MUO: P < 0.001
- Between MHO and MUO: P = 0.005
- Between MHO and MUO: P < 0.001
- Between MHO and MUO: P = 0.041
- Between MHO and MUO: P = 0.021
- Between MHO and MUO: P = 0.003
- Between MHO and MUO: P = 0.015
- Between MHO and MUO: P = 0.016
Observational data: associations, not effects.
Original publication
Distinguishing health-related parameters between metabolically healthy and metabolically unhealthy obesity in women. Int J Obes (Lond). Published 11 April 2024. doi:10.
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