Pre‐pregnancy maternal obesity and infant neurodevelopmental outcomes in Latino infants
Authors' conclusion
Managing maternal obesity pre-pregnancy is crucial for improving infant neurodevelopmental outcomes, especially in low-income Latino families. Promoting healthy weight and enhancing infant diet quality can enhance neurodevelopment in these populations.
Study context
- Population
- Low-income Latino mother-infant pairs enrolled at 1 month post partum and followed for 2 years; maternal pre-pregnancy anthropometrics self-reported
- Participants
- 163 mother-infant pairs
- Exposure
- Maternal pre-pregnancy BMI
- Outcome
- Child neurodevelopment (Bayley Scales of Infant Development)
- Follow-up
- 24 months
Methodological detailslongitudinal, assessments at 6-month intervals, mediation and regression models adjusted for maternal factors
- Longitudinal
- Assessments at 6-month intervals
- Mediation and regression models adjusted for maternal factors
Main finding
As reported in the abstract
Association of pre-pregnancy BMI with child neurodevelopment
Β, cognitive score
−0.1
95% CI −0.2 to −0.06P < 0.001
Pre-pregnancy BMI
Β, language score
−0.1
95% CI −0.2 to −0.03P = 0.01
Pre-pregnancy BMI
Observational data: associations, not effects.
Further findings
Mediation by infant diet quality (HEI-2015 score at 24 months)
- Share of total effect on cognitive subscale mediated by infant HEI-2015 score (partial mediation)
- 23%
- Share of total effect on language subscale mediated by infant HEI-2015 score (partial mediation)
- 30%
- No specific infant dietary components mediated the relationship, except for the total HEI-2015 score
Original publication
Pre‐pregnancy maternal obesity and infant neurodevelopmental outcomes in Latino infants. Obesity (Silver Spring). Published 10 April 2024. doi:10.
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