Timing of Moderate to Vigorous Physical Activity, Mortality, Cardiovascular Disease, and Microvascular Disease in Adults With Obesity
Authors' conclusion
Aerobic MVPA bouts undertaken in the evening were associated with the lowest risk of mortality, CVD, and MVD. Timing of physical activity may play a role in the future of obesity and T2D management.
Study context
- Population
- Adults with obesity (BMI ≥30 kg/m²), and a subset with T2D, UK Biobank accelerometry substudy; mean age 62.2 (SD 7.7) yearsT2D subset n = 2,995
- Participants
- 29,836 adults
- Exposure
- Morning, afternoon or evening aerobic moderate to vigorous physical activity (MVPA) vs <1 aerobic MVPA bout per day
- Outcome
- All-cause mortality, CVD and MVD
- Follow-up
- Mean 7.9 (SD 0.8) years
Methodological detailsaccelerometry substudy, adjusted for established and potential confounders
- Accelerometry substudy
- Adjusted for established and potential confounders
Main finding
As reported in the abstract
All-cause mortality
Each group vs referenceHazard ratio (95% CI)
Evening
0.39(0.27–0.55)
Afternoon
0.60(0.51–0.71)
Morning
0.67(0.56–0.79)
- Deaths
- 1,425
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CVD incidenceEveningvs Reference | 0.64 (0.54–0.75) | |
| MVD incidenceEveningvs Reference | 0.76 (0.63–0.92) | |
| 0.512Hazard ratio (log scale) |
- Cardiovascular disease (CVD) incidence — CVD events
- 3,980
- Microvascular disease (MVD) incidence — MVD events
- 2,162
CVD incidence
- Evening MVPA associated with the lowest risk of CVD
MVD incidence
- Evening MVPA associated with the lowest risk of MVD
T2D subset
- Findings were similar in the T2D subset
Original publication
Timing of Moderate to Vigorous Physical Activity, Mortality, Cardiovascular Disease, and Microvascular Disease in Adults With Obesity. Diabetes Care. Published 10 April 2024. doi:10.
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