Timing of Meal Consumption on Glucose Profiles in Latino Adolescents with Obesity
Authors' conclusion
Similar to findings in adults at risk for diabetes, Latino youth with obesity show greater insulin resistance in response to a meal consumed in the afternoon and evening compared to early morning food consumption.
Study context
- Population
- Latino adolescents aged 13–19 years with obesity, at high risk of T2D; 78% female, mean age 16.5 ± 1.3 years, 70% publicly insuredconsented
- Participants
- 22 adolescents
- Comparison
- Same test-meal consumed in the morning, afternoon and evening
- Outcome
- Co-primary: AUC for glucose, insulin and C-peptide, and insulinogenic index (IGI), on mixed meal tolerance test (MMTT) after the test-meal following a 16 h fast
Methodological detailswithin-participant design
- Within-participant design
Main finding
As reported in the abstract
AUC glucose, insulin, C-peptide and IGI
- 4:00 p.m. vs 8:00 a.m.: P = 0.003
- 4:00 p.m. vs 8:00 a.m.: P < 0.001
- 4:00 p.m. vs 8:00 a.m.: P = 0.09
- 4:00 p.m. vs 8:00 a.m.: P = 0.027
Further findings
| Outcome | P value |
|---|---|
| Rise in glucose and C-peptide levels4:00 p.m. vs 8:00 a.m. · greater rise at 4:00 p.m. | P = 0.006 |
| Rise in glucose and C-peptide levels4:00 p.m. vs 8:00 a.m. · greater rise at 4:00 p.m. | P < 0.0001 |
Rise in glucose and C-peptide levels
- No significant association between insulin levels and timing of meal consumption
Original publication
Timing of Meal Consumption on Glucose Profiles in Latino Adolescents with Obesity. Horm Res Paediatr. Published 11 June 2024. doi:10.
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