Associations of childhood body mass index (BMI), general and visceral fat mass with metabolite profiles at school-age
Authors' conclusion
An adverse childhood body fat profile, characterized by higher BMI and total body fat mass, is associated with metabolic alterations, particularly in amino acids, phospholipids, and carnitines. Fewer associations were present for visceral fat mass. We identified a metabolite profile that improved the identification of impaired cardiometabolic health in children, compared to BMI only.
Study context
- Population
- School-age children, mean age 9.8 (95% range 9.1, 10.6) years, in a population-based cohort; BMI, total body fat mass (DXA) and visceral fat mass (MRI) vs serum metabolites (LC-MS/MS)
- Participants
- 497 children
- Exposure
- BMI vs BMI + Metabolites
- Outcome
- Associations of BMI, total body fat mass and visceral fat mass with serum metabolites
Methodological detailspopulation-based cohort
- Population-based cohort
Main finding
As reported in the abstract
- Higher BMI also associated with higher aromatic amino-acids and alkyl-lysophosphatidylcholines
- FDR-corrected p-values < 0.05
- Strongest associations for Lyso.PC.a.C14.0 and SM.a.C32.2
- FDR-corrected p-values < 0.01
- Higher visceral fat mass associated only with higher concentrations of individual metabolites, particularly Lyso.PC.a.C14.0, PC.aa.C32.1 and SM.a.C32.2
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Observational data: associations, not effects.
Further findings
AUC
| Outcome | BMI | BMI + Metabolites |
|---|---|---|
| Prediction of a metabolically unhealthy phenotype | 0.59 (95% CI 0.47,0.71) | 0.91 (95% CI 0.85,0.97) |
- Prediction of a metabolically unhealthy phenotype — Selected metabolites that improved prediction vs BMI only
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Original publication
Associations of childhood BMI, general and visceral fat mass with metabolite profiles at school-age. Int J Obes (Lond). Published 8 June 2024. doi:10.
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