Intermediate versus morning chronotype has lower vascular insulin sensitivity in adults with obesity
Authors' conclusion
When measured during the morning, INT had a lower vascular insulin sensitivity than MORN. Additional work is needed to understand endothelial function differences among chronotypes to optimize cardiovascular disease risk reduction.
Study context
- Population
- Adults with obesity classified by Morningness-Eveningness Questionnaire (MEQ); MORN 53.8 ± 6.7 years, 35.3 ± 4.9 kg/m²; INT 56.6 ± 9.0 years, 35.7 ± 6.1 kg/m²
- Exposure
- Intermediate vs morning chronotype
- Outcome
- Vascular insulin sensitivity during 120 min euglycaemic-hyperinsulinaemic clamp: macrovascular (brachial %FMD, post-ischaemic flow velocity) and microvascular (contrast-enhanced US microvascular blood volume)
- Follow-up
- 120 min
Main finding
As reported in the abstract
- Insulin lowered FMD corrected to shear stress and microvascular blood volume in INT vs MORN
- Fasting FMD similar between groups
- INT vs MORN: both p ≤ .02
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| VO2maxMORN vs INT · higher with MORN | P < 0.01 |
| Fasting nitrateINT vs MORN · lower with INT | P = 0.03 |
| Fasting arginineINT vs MORN · lower with INT | P = 0.07 |
VO2max
- No difference in fat mass
Correlations of higher MEQ with vascular measures · 120 min
- Higher MEQ vs elevated FMD
- r = 0.33, p = .03
- Higher MEQ vs lower post-ischaemic flow velocity
- r = −0.33, p = .03
- Higher MEQ vs lower shear rate
- r = −0.36, p = .02
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Intermediate versus morning chronotype has lower vascular insulin sensitivity in adults with obesity. Diabetes Obes Metab. Published 21 January 2024. doi:10.
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