The MetaboHealth Score Enhances Insulin Resistance Metabotyping for Targeted Fat Loss: The PERSON Study
Authors' conclusion
Combining metabotype with MetaboHealth may enhance personalized dietary strategies for fat loss in insulin-resistant adults.
Study context
- Population
- Adults aged 40–75 with insulin resistance (IR) (muscle or liver IR metabotypes), grouped into MetaboHealth tertiles (higher = poorer health)184 with complete data
- Participants
- 242 adults
- Comparison
- Low-fat, high-protein, high-fiber diet vs high-monounsaturated fatty acid diet, by IR metabotype and MetaboHealth tertile
Methodological detailsisocaloric diets, four-way interaction analysis (linear mixed models)
- Isocaloric diets
- Four-way interaction analysis (linear mixed models)
Primary result
As reported in the abstract
Interaction of MetaboHealth with IR metabotype and diet on cardiometabolic and body composition outcomes · 12 weeks
- No interaction was observed for cardiometabolic outcomes
- Significant interactions for android, gynoid, total fat percentage and fat mass index
- Healthiest tertile: matched diets led to greater fat loss
- Poorest tertile: both diets similarly effective
Further findings
MetaboHealth score · 12 weeks
- MetaboHealth remained unchanged
Original publication
The MetaboHealth Score Enhances Insulin Resistance Metabotyping for Targeted Fat Loss: The PERSON Study. Obesity (Silver Spring). Published 14 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →