Dietary Protein Reduction During Isocaloric Conditions Reduces Body Weight in Men With Overweight or Obesity
Authors' conclusion
These findings suggest that reducing protein intake (0.9 g kg-1 BW day-1), substituted with increased carbohydrates, compared with a habitual protein intake (1.8 g kg-1 BW day-1), can induce weight loss without restricting total energy intake in men with overweight or obesity.
Study context
- Population
- Men with overweight or obesity
- Participants
- 17 men
- Comparison
- Protein-reduced diet vs habitual diet
Methodological detailshighly controlled isocaloric diets
- Highly controlled isocaloric diets
Primary result
As reported in the abstract
Body weight · 5 weeks
Protein reduction induced weight loss vs higher protein intake, without caloric restriction
2.0 ± 0.6 kg
Further findings
Plasma FGF21
- Protein reduction increased plasma FGF21 vs higher protein intake
Association of FGF21 changes with body weight changes
- Changes in plasma FGF21 inversely associated with changes in body weight
- r = −0.59, p = 0.02
Adipose tissue FGF21 receptor complex and downstream targets
- FGFR1, β-klotho and downstream targets in subcutaneous adipose tissue unchanged
Skeletal muscle mitochondrial oxidative phosphorylation markers
- Markers unaltered
Body composition
- Fat mass decreased significantly; lean body mass only tended to decrease
Original publication
Dietary Protein Reduction During Isocaloric Conditions Reduces Body Weight in Men With Overweight or Obesity. Obesity (Silver Spring). Published 16 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →