The Association and Joint Effect of Adipocyte Fatty Acid Binding Protein and Obesity Phenotype With Cardiovascular Events
Authors' conclusion
Serum A-FABP levels were significantly associated with the risk of cardiovascular events, and this pattern of association was more prominent among the population with low fat%, which was independent of VFA.
Study context
- Population
- Residents without previous CVD at baseline, with body composition and serum adipocyte fatty acid binding protein (A-FABP) data; fat% by bioelectrical impedance, visceral fat area (VFA) by MRI579 men · 766 women
- Participants
- 1,345 residents
- Exposure
- Serum A-FABP levels and obesity phenotype (fat%, VFA) and incident cardiovascular events
- Outcome
- Incident cardiovascular events
- Follow-up
- Mean 7.6 years
Main finding
As reported in the abstract
Cardiovascular events
Cardiovascular events (13.9 per 1000 person-years)
136
HR per 1-unit increase in loge-transformed A-FABP
1.87
95% CI 1.33–2.63
HR highest tertile of fat%
2.38
95% CI 1.49–3.81
HR highest tertile of VFA
1.79
95% CI 1.09–2.93
Observational data: associations, not effects.
Further findings
A-FABP–CV events association by obesity phenotype
- Association more pronounced in participants with low fat%, regardless of VFA levels
- Joint effect of high A-FABP levels and obesity resulted in a greater risk of CV events
Original publication
The Association and Joint Effect of Adipocyte Fatty Acid Binding Protein and Obesity Phenotype With Cardiovascular Events. J Clin Endocrinol Metab. Published 27 February 2023. doi:10.
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