Beyond BMI : Genome‐Wide Associations of Visceral Fat, Fat Mass, and Fat‐Free Mass in Eastern Asian Populations
Authors' conclusion
We found that visceral fat, fat mass, and fat-free mass were governed by partially distinct genetic mechanisms not fully captured by BMI.
Study context
- Population
- Adults from a population-based biobank in East Asia; body composition by bioelectrical impedance analysis
- Participants
- 14,121 adults
- Outcome
- Genetic associations with visceral fat, fat mass and fat-free mass
Methodological detailspopulation-based biobank, adjusted for BMI and confounders
- Population-based biobank
- Adjusted for BMI and confounders
Main finding
As reported in the abstract
- Multiple SNPs significantly associated with visceral fat, fat mass and fat-free mass
- TTN-rs794727539 variant inversely associated with visceral fat and positively with fat-free mass, independent of BMI
- Additional loci showed trait-specific associations; many fat-mass-associated variants attenuated after BMI adjustment
Observational data: associations, not effects.
Original publication
Beyond BMI : Genome‐Wide Associations of Visceral Fat, Fat Mass, and Fat‐Free Mass in Eastern Asian Populations. Obesity (Silver Spring). Published 28 August 2026. doi:10.
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