Body Composition and Lifestyle Interventions in Pharmacological Treatment of Acquired Hypothalamic Obesity: A Systematic Review of Randomized Controlled Trials
Authors' conclusion
Current evidence suggests that selected pharmacological interventions may improve weight-related and body composition outcomes in aHO; however, evidence remains limited and of predominantly low certainty.
Study context
- Population
- Patients of any age with acquired hypothalamic obesity (aHO); Randomized controlled trials (RCTs) published July 24, 2015 to November 8, 20257 RCTs
- Comparison
- Pharmacological and/or lifestyle weight management interventions in acquired hypothalamic obesity
- Outcome
- Anthropometric and body composition outcomes
Methodological detailsdescriptive synthesis only, Grading of Recommendations Assessment, Development and Evaluation (GRADE) certainty assessment, adapted Cochrane Risk of Bias Tool, Searches of PubMed, Embase, the Cochrane Library, CINAHL and CNKI
- Descriptive synthesis only
- GRADE certainty assessment
- Adapted Cochrane Risk of Bias Tool
- Searches of PubMed, Embase, the Cochrane Library, CINAHL and CNKI
Pooled result
As reported in the abstract
- Certainty of evidence for anthropometric/body composition outcomes (GRADE)
- low
Further pooled results
Behavioral and metabolic outcomes
- Certainty of evidence for metabolic and behavioral/energy outcomes (GRADE)
- low
- Several interventions improved satiety and reduced hunger
- Metabolic findings were inconsistent across studies
Risk of bias
- Studies at high risk of bias
- 1
- Studies with some concerns
- 1
Safety
- Certainty of evidence for adverse events (GRADE)
- moderate
- Adverse events were mostly mild to moderate
Original publication
Body Composition and Lifestyle Interventions in Pharmacological Treatment of Acquired Hypothalamic Obesity: A Systematic Review of Randomized Controlled Trials. Obesity (Silver Spring). Published 26 August 2026. doi:10.
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