Association between insulin sensitivity and lean mass loss during weight loss
Authors' conclusion
Identifying individuals with low insulin sensitivity prior to weight loss interventions may allow for a personalized approach aiming at minimizing LM loss.
Study context
- Population
- Individuals undergoing weight loss; baseline BMI 32.1 ± 3.8 kg/m²
- Participants
- 57 individuals
- Comparison
- Association of baseline insulin sensitivity (sensitivity index (SI)) with changes in total lean mass (LM) and appendicular LM (ALM) during weight loss
- Primary endpoint
- Relationship between baseline SI (intravenous glucose tolerance test) and changes in total LM and ALM (DXA) during weight loss
- Follow-up
- 16 weeks
Primary result
As reported in the abstract
Association of baseline SI with change in total LM (kg)
SI inversely associated with change in total LM (multiple regression), β
0.481
p < 0.001
Further findings
Association of baseline SI with ALM loss · 16 weeks
- Similar association of SI with ALM loss, β
- 0.359, p < 0.05
Change in body weight, LM and ALM · 16 weeks
- Mean body weight lost
- 6.8 ± 3.2 kg (p < 0.001)
- LM lost
- 1.5 ± 2.6 kg (p < 0.05)
- ALM lost
- 0.5 ± 0.73 kg (p < 0.05)
Original publication
Association between insulin sensitivity and lean mass loss during weight loss. Obesity (Silver Spring). Published 28 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →