Clinical phenotypes of adults with monogenic and syndromic genetic obesity
Authors' conclusion
We found distinct phenotypes in adult genetic obesity. Additionally, we demonstrated low sensitivity for detecting genetic obesity in adults using pediatric ES recommendations, necessitating specific genetic testing recommendations in adult obesity care.
Study context
- Population
- Adults with genetic obesity (monogenic obesity (MO) or syndromic obesity (SO)) and adults with common obesity as controls79 with genetic obesity
- Participants
- 32 / 47 / 186
- Exposure
- Adults with monogenic obesity vs syndromic obesity vs common obesity
- MOn = 32
- SOn = 47
- Common obesity (CO)n = 186reference
- Outcome
- Age of onset of obesity
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
BMI
Increased appetite — between MO and CO · across MO, SO and CO
P < 0.001
Intellectual deficit
Autism spectrum disorder
Endocrine Society pediatric genetic-testing recommendations fulfilled — between MO and CO · across MO, SO and CO
P < 0.001
BMI
- Median BMI was similar among the groups
Original publication
Clinical phenotypes of adults with monogenic and syndromic genetic obesity. Obesity (Silver Spring). Published 28 May 2024. doi:10.
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