Associations between regional adipose tissue distribution and skeletal muscle bioenergetics in older men and women
Authors' conclusion
Skeletal MFI and abdominal visceral, but not subcutaneous, AT are inversely associated with SM mitochondrial bioenergetics in older adults independent of BMI. Associations between ectopic AT and in vivo mitochondrial bioenergetics are attenuated by PA.
Study context
- Population
- Adults ≥70 years of age
- Participants
- 829 adults
- Outcome
- Associations of ectopic AT (abdominal, subcutaneous, visceral AT; thigh MFI by MRI) with skeletal muscle (SM) mitochondrial bioenergetics (in vivo ATPmax by 31P-MRS; ex vivo maximal OXPHOS)
Main finding
As reported in the abstract
Associations of AT depots with SM mitochondrial bioenergetics (linear regression)
- Total abdominal adipose tissue (AT) vs ATPmax, independent of BMI (p < 0.01; n = 770)
- Std. β = −0.21; R2 = 0.09
- Visceral AT vs ATPmax, independent of BMI (p < 0.01; n = 770)
- Std. β = −0.16; R2 = 0.09
- Visceral AT vs carbohydrate-supported maximal OXPHOS, independent of BMI and PA (p < 0.05; n = 609)
- Std. β = −0.16; R2 = 0.25
- Thigh muscle fat infiltration (MFI) vs carbohydrate-supported maximal OXPHOS, independent of BMI and PA (p < 0.05; n = 609)
- Std. β = −0.11; R2 = 0.24
- Total abdominal AT vs fatty acid-supported maximal OXPHOS, independent of BMI and PA (p < 0.05; n = 447)
- Std. β = −0.19; R2 = 0.24
- Visceral AT vs fatty acid-supported maximal OXPHOS, independent of BMI and PA (p < 0.05; n = 447)
- Std. β = −0.17; R2 = 0.24
Observational data: associations, not effects.
Original publication
Associations between regional adipose tissue distribution and skeletal muscle bioenergetics in older men and women. Obesity (Silver Spring). Published 28 May 2024. doi:10.
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