Plasma-derived exosomal miRNAs as potentially novel biomarkers for latent autoimmune diabetes in adults
Authors' conclusion
This study uncovers the miRNA profiles of plasma-derived exosomes from LADA patients and identifies exosomal miRNAs as potential biomarkers to discriminate LADA from T2D for the first time. Our data demonstrate the function of exosomal miRNAs in the development of LADA and contribute to an in-depth understanding of the precise mechanisms underlying the pathogenesis of LADA.
Study context
- Population
- Patients with latent autoimmune diabetes in adults (LADA), healthy controls and patients with T2D
- Comparison
- LADA vs T2D; LADA vs healthy controls
- Controln = 5reference
- Outcome
- Discrimination of LADA from T2D by exosomal miRNAs (AUC)
Methodological detailsexosomal miRNA profiling, quantitative real-time PCR (qRT-PCR) validation in a larger cohort
- Exosomal miRNA profiling
- qRT-PCR validation in a larger cohort
Performance
As reported in the abstract
| Test or model | AUC |
|---|---|
| hsa-miR-146a-5p | 0.978 |
| hsa-miR-223-3p | 0.96 |
| hsa-miR-21-5p | 0.809 |
AUC
hsa-miR-146a-5p0.978
hsa-miR-223-3p0.96
hsa-miR-21-5p0.809
Further findings
Differentially expressed plasma exosomal miRNAs, LADA vs healthy subjects
- Differentially expressed exosomal miRNAs identified
- 75
Original publication
Plasma-derived exosomal miRNAs as potentially novel biomarkers for latent autoimmune diabetes in adults. Diabetes Res Clin Pract. Published 4 February 2023. doi:10.
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