Outcomes in children of women with type 2 diabetes exposed to metformin versus placebo during pregnancy (MiTy Kids): a 24-month follow-up of the MiTy randomised controlled trial
Primary result · BMI Z scoreResult — go to the resultMean difference 0.07 95% CI −0.31 to 0.45Authors' conclusion
Anthropometrics were similar in children exposed and those not exposed to metformin in utero; hence, overall, data are reassuring with regard to the use of metformin during pregnancy in women with type 2 diabetes and the long-term health of their children.
Study context
- Population
- Children of women with T2D from the MiTy trial, followed to 24 months of age; 19 centres in Canada and Australiaof 465 eligible
- Participants
- 283 children
- Comparison
- In-utero metformin vs placebo exposure
- Primary endpoint
- BMI Z score and sum of skinfolds, adjusted for confounders
- Follow-up
- Up to 24 months
Methodological detailsmasked caregivers and researchers, multicentre (19 centres, Canada and Australia), 24-month follow-up
- Masked caregivers and researchers
- Multicentre (19 centres, Canada and Australia)
- 24-month follow-up
Primary result
BMI Z score
Mean difference
0.07
95% CI −0.31 to 0.45
P = 0.72
By group
Metformin
0.84
mean · SD 1.52
Placebo
0.91
mean · SD 1.38
Placebovs Metformin
mean difference 0.07 (95% CI −0.31 to 0.45); P = 0.72
As reported in the abstract
Further findings
Mean, mm
| Outcome | Metformin | Placebo | Mean difference (mm) (CI) | P value | |
|---|---|---|---|---|---|
| Sum of skinfolds · up to 24 months | 23.0 (SD 5.2) | 23.8 (SD 5.4) | 0.8 (−0.7 to 2.3) | P = 0.31 | |
| −10123Difference, mm (linear scale) |
| Outcome | Mean difference (95% CI) | P value | |
|---|---|---|---|
| Metformin as predictor of BMI Z score · up to 24 months | −0.01 (−0.42 to 0.37) | P = 0.92 | |
| −0.6−0.4−0.200.20.4Difference (linear scale) |
Sum of skinfolds · up to 24 months
- No difference between groups in mean sum of skinfolds
Metformin as predictor of BMI Z score · up to 24 months
- Metformin was not a predictor of BMI Z score
BMI trajectory
- In males, trajectories significantly different by treatment; BMI higher with metformin between 6 and 24 months
- P = 0.048
- No overall difference in BMI trajectory
Weight vs WHO reference population
- Children of women with T2D ≈1 SD heavier than WHO reference population
Original publication
Outcomes in children of women with type 2 diabetes exposed to metformin versus placebo during pregnancy (MiTy Kids): a 24-month follow-up of the MiTy randomised controlled trial. Lancet Diabetes Endocrinol. Published 3 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →