In Utero Exposure to Maternal Hyperglycemia and Offspring Type 2 Diabetes Genetic Risk Score Are Independently Associated With Risk of Impaired Glucose Tolerance in Youth
Authors' conclusion
High genetic risk for diabetes and in utero exposure to maternal hyperglycemia are additively associated with IGT + T2D and glycemic outcomes in youth.
Study context
- Population
- Children aged 10–14 years from the Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study; mean age 11.4 years
- Participants
- 3,444 children
- Exposure
- In utero exposure to maternal hyperglycemia and child T2D-GRS
- Outcome
- Impaired glucose tolerance (IGT) + T2D and continuous glycemic outcomes
- Follow-up
- 10-14 years old
Methodological detailsMaternal OGTT at ∼28 weeks' gestation, T2D-GRS calculated from 1,150 known genetic variants associated with T2D in adults
- Maternal OGTT at ∼28 weeks' gestation
- T2D-GRS calculated from 1,150 known genetic variants associated with T2D in adults
Main finding
As reported in the abstract
IGT + T2D · 10-14 years
Observational data: associations, not effects.
Original publication
In Utero Exposure to Maternal Hyperglycemia and Offspring Type 2 Diabetes Genetic Risk Score Are Independently Associated With Risk of Impaired Glucose Tolerance in Youth. Diabetes Care. Published 19 May 2025. doi:10.
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