Fetal and post‐natal outcomes in offspring after intrauterine metformin exposure: A systematic review and meta‐analysis of animal experiments
Authors' conclusion
This systematic review was unable to establish effects of metformin treatment during pregnancy on anthropometric, cardiovascular and metabolic outcomes in non-human offspring. Heterogeneity between studies was high and reporting of methodological details often limited. This highlights a need for additional high-quality research both in humans and model systems to allow firm conclusions to be established. Future research should include focus on the effects of metformin in older offspring age groups, and on outcomes which have gone uninvestigated to date.
Study context
- Population
- Offspring in controlled animal studies (95% rodent, 5% pig models); follow-up from birth to 2 years of age37 articles · 716 litters
- Participants
- 3,133 offspring
- Comparison
- Intrauterine metformin exposure vs control
- Outcome
- Offspring anthropometric, cardiovascular and metabolic outcomes
Methodological detailsrandom effects model, standardized mean difference, Risk of bias unclear in most studies due to poor reporting of methodological details
- Random effects model
- Standardized mean difference
- Risk of bias unclear in most studies due to poor reporting of methodological details
Pooled result
As reported in the abstract
Anthropometric, cardiovascular and metabolic offspring outcomes
- No significant effects of metformin on any anthropometric, cardiovascular or metabolic offspring outcome in the overall meta-analysis
- 34 articles in meta-analysis
- Between-studies heterogeneity high
Original publication
Fetal and post‐natal outcomes in offspring after intrauterine metformin exposure: A systematic review and meta‐analysis of animal experiments. Diabet Med. Published 26 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →