Physical Activity, Cardiovascular Status, Mortality, and Prediabetes in Hispanic and Non-Hispanic Adults
Authors' conclusion
In this cohort study of US Hispanic or Latino and non-Hispanic adults, lower moderate to vigorous PA levels were associated with CVD or mortality among participants with normoglycemia but not participants with prediabetes. Adults with prediabetes may benefit from reducing sedentary behavior and improving multiple lifestyle factors beyond improving moderate to vigorous PA alone.
Study context
- Population
- Hispanic or Latino (HCHS/SOL) and non-Hispanic (Framingham Heart Study (FHS)) adults with prediabetes or normoglycemia, free of cardiovascular disease (CVD) at baselineHCHS/SOL 9456
- Participants
- 13,223 participants
- Exposure
- Insufficient vs sufficient moderate to vigorous physical activity (PA) to meet 2018 PAG, by prediabetes status
- Outcome
- Composite of:
- Incident CVD
- All-cause mortality
- Follow-up
- Median 7.8 (IQR 7.2-8.5) years in HCHS/SOL and 9.6 (IQR 8.1-10.7) years in FHS
Methodological details2 cohorts (HCHS/SOL and FHS), accelerometry-measured exposure, Analyses conducted between September 1, 2022, and January 10, 2024
- 2 cohorts (HCHS/SOL and FHS)
- Accelerometry-measured exposure
- Analyses conducted between September 1, 2022, and January 10, 2024
Main finding
As reported in the abstract
Composite of:
- Incident CVD
- All-cause mortality
PAG not met vs PAG metHazard ratio (95% CI)
Normoglycemia
1.85(1.12–3.06)
Prediabetes
1.07(0.72–1.58)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Composite outcome, steps <7000 vs ≥7000 per day (HCHS/SOL)Steps <7000/dayvs Steps ≥7000/dayNormoglycemia | 1.58 (0.85–2.93) | |
| Composite outcome, steps <7000 vs ≥7000 per day (HCHS/SOL)Steps <7000/dayvs Steps ≥7000/dayPrediabetes | 1.08 (0.67–1.74) | |
| 0.20.5125Hazard ratio (log scale) |
Composite outcome, steps <7000 vs ≥7000 per day (HCHS/SOL)
- No statistically significant association between the composite outcome and other PA metrics in HCHS/SOL
Composite outcome per 30 min/day of sedentary behavior (HCHS/SOL)
- HR per 30 min/day sedentary behavior, prediabetes
- 1.05 (95% CI 0.99-1.12)
- HR per 30 min/day sedentary behavior, normoglycemia
- 1.07 (95% CI 0.98-1.16)
- No association; similar in both groups
Original publication
Physical Activity, Cardiovascular Status, Mortality, and Prediabetes in Hispanic and Non-Hispanic Adults. JAMA Netw Open. Published 3 June 2024. doi:10.
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